MDCO-216 Does Not Induce Adverse Immunostimulation, in Contrast to Its Predecessor ETC-216
نویسندگان
چکیده
منابع مشابه
Dmd061812 208..216
The aim of this study was to further characterize the expression and function of human CYP2B6 in a recently generated CYP2A13/ 2B6/2F1-transgenic (TG) mouse model, in which CYP2B6 is expressed selectively in the liver. The inducibility of CYP2B6 by phenobarbital (PB) and dexamethasone (DEX), known inducers of CYP2B6 in human liver, was examined in the TG mice, as well as in TG/Cyp2abfgs-null (o...
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The human sense of shape and pattern recognition can discern subtle nuances among groups of visual cues that no computer system can reproduce faithfully. Yet when it comes to measuring and evaluating chromatograms, analysts put a great deal of faith into their computerized data-handling systems. During the course of one year, a practising chromatographer might look at 10 000 or more peaks. Afte...
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Fuzzy C-means (FCM) is an unsupervised clustering technique that is often used for the unsuper-vised segmentation of multivariate images. In traditional FCM the clustering is based on spectral information only and the geometrical relationship between neighbouring pixels is not used in the clustering procedure. In this paper, the spatially guided FCM (SG-FCM) algorithm is presented which segment...
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Alzheimer’s disease is one of the most common causes of death worldwide, with poor treatment options. A tissue landmark of Alzheimer’s disease is accumulation of the anomalous protein amyloid-b in specific brain areas. Whether inflammation is an effect of amyloid-b on the Alzheimer’s disease brain, or rather it represents a cause for formation of amyloid plaques and intracellular tangles remain...
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Tradeoffs centrally mediate the expression of human adaptations. We propose that tradeoffs also influence the prevalence and forms of human maladaptation manifest in disease. By this logic, increased risk for one set of diseases commonly engenders decreased risk for another, diametric, set of diseases. We describe evidence for such diametric sets of diseases from epidemiological, genetic and mo...
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ژورنال
عنوان ژورنال: Cardiovascular Drugs and Therapy
سال: 2017
ISSN: 0920-3206,1573-7241
DOI: 10.1007/s10557-017-6746-x